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Mouse Anti-STRADA Recombinant Antibody (CBYCL-636) (CBMAB-L0537-YC)

Provided herein is a Mouse monoclonal antibody against Human STRADA. The antibody can be used for immunoassay techniques, such as WB, ELISA.
See all STRADA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-636
Antibody Isotype
IgG2a
Application
WB, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
STE20-Related Kinase Adaptor Alpha
Introduction
STRADA contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Additional transcript variants have been described but their full-length nature is not known.
Entrez Gene ID
92335
UniProt ID
Q7RTN6
Alternative Names
2610019A05Rik; 6030402H20Rik; AI480680; E130112C09Rik
Function
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
Biological Process
Biological Process activation of protein kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process G1 to G0 transitionManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process protein export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Involvement in disease
A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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