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Mouse Anti-STRADB (AA 319-418) Recombinant Antibody (CBXS-0805) (CBMAB-S3732-CQ)

This product is a mouse antibody that recognizes STRADB. The antibody CBXS-0805 can be used for immunoassay techniques such as: ELISA, WB.
See all STRADB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0805
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 319-418

Target

Full Name
STE20-related kinase adaptor beta
Introduction
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
55437
UniProt ID
Q9C0K7
Alternative Names
ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK; PRO1038
Function
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).
Biological Process
Biological Process activation of protein kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell morphogenesisIEA:Ensembl
Biological Process JNK cascadeIEA:Ensembl
Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA:Ensembl
Biological Process protein export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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