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Mouse Anti-STX17 Recombinant Antibody (CBXS-3672) (CBMAB-S0951-CQ)

This product is a mouse antibody that recognizes STX17. The antibody CBXS-3672 can be used for immunoassay techniques such as: WB.
See all STX17 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3672
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the center region of human STX17
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.32 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Syntaxin 17
Introduction
This locus represents naturally occurring read-through transcription between the neighboring syntaxin 16 (STX16) and aminopeptidase-like 1 (NPEPL1) genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product.
Entrez Gene ID
55014
UniProt ID
P56962
Alternative Names
Syntaxin 17
Function
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502).
STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502, PubMed:28504273).
May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).
Biological Process
Biological Process autophagosome maturationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process autophagosome membrane dockingManual Assertion Based On ExperimentIDA:GO_Central
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endoplasmic reticulum-Golgi intermediate compartment organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein localization to phagophore assembly siteManual Assertion Based On ExperimentIDA:MGI
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
Smooth endoplasmic reticulum membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Cytoplasmic vesicle, autophagosome membrane
Cytoplasmic vesicle, COPII-coated vesicle membrane
Cytoplasm, cytosol
Mitochondrion membrane
Has a hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (PubMed:23217709).
Topology
Cytoplasmic: 2-228
Helical: 229-249
Lumenal: 250-254
Helical: 255-275
Cytoplasmic: 276-302
PTM
Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2; regulates exit from the endoplasmic reticulum (By similarity).
(Microbial infection) Cleaved by the L.pneumophila serine protease Lpg1137, impairing endoplasmic reticulum-mitochondria communication, leading to inhibit autophagy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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