Mouse Anti-SULF2 Recombinant Antibody (CBXS-4396) (CBMAB-S0240-CQ)

Name: Mouse Anti-SULF2 Recombinant Antibody (CBXS-4396)
SKU: CBMAB-S0240-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4396

Application

WB, FC, ELISA, IHC, IP, IHC-P, CyTOF

Immunogen

Partial recombinant human Sulfatase 2 isoform b [Accession# NP_940998]

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

sulfatase 2

Introduction

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).

Entrez Gene ID

Human	55959
Mouse	72043

UniProt ID

Human	Q8IWU5
Mouse	Q8CFG0

Alternative Names

HSULF-2

Function

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

Biological Process

Biological Process bone developmentISS:BHF-UCL
Biological Process cartilage developmentISS:UniProtKB
Biological Process chondrocyte developmentISS:UniProtKB
Biological Process embryonic skeletal system developmentISS:UniProtKB
Biological Process esophagus smooth muscle contractionISS:UniProtKB
Biological Process glial cell-derived neurotrophic factor receptor signaling pathwayISS:UniProtKB
Biological Process glomerular basement membrane developmentISS:UniProtKB
Biological Process glomerular filtrationISS:UniProtKB
Biological Process heparan sulfate proteoglycan metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innervationISS:UniProtKB
Biological Process kidney developmentISS:BHF-UCL
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwayISS:UniProtKB
Biological Process positive regulation of vascular endothelial growth factor productionISS:UniProtKB
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Endoplasmic reticulum
Golgi apparatus, Golgi stack
Cell surface
Also localized on the cell surface.

PTM

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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