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Mouse Anti-SULF2 Recombinant Antibody (CBXS-4396) (CBMAB-S0240-CQ)

This product is a mouse antibody that recognizes SULF2. The antibody CBXS-4396 can be used for immunoassay techniques such as: WB, FC, ELISA, IHC, IP, IHC-P, CyTOF.
See all SULF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBXS-4396
Antibody Isotype
IgG1
Application
WB, FC, ELISA, IHC, IP, IHC-P, CyTOF

Basic Information

Immunogen
Partial recombinant human Sulfatase 2 isoform b [Accession# NP_940998]
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sulfatase 2
Introduction
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).
Entrez Gene ID
Human55959
Mouse72043
UniProt ID
HumanQ8IWU5
MouseQ8CFG0
Alternative Names
HSULF-2
Function
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Biological Process
Biological Process bone developmentISS:BHF-UCL
Biological Process cartilage developmentISS:UniProtKB
Biological Process chondrocyte developmentISS:UniProtKB
Biological Process embryonic skeletal system developmentISS:UniProtKB
Biological Process esophagus smooth muscle contractionISS:UniProtKB
Biological Process glial cell-derived neurotrophic factor receptor signaling pathwayISS:UniProtKB
Biological Process glomerular basement membrane developmentISS:UniProtKB
Biological Process glomerular filtrationISS:UniProtKB
Biological Process heparan sulfate proteoglycan metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innervationISS:UniProtKB
Biological Process kidney developmentISS:BHF-UCL
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwayISS:UniProtKB
Biological Process positive regulation of vascular endothelial growth factor productionISS:UniProtKB
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum
Golgi apparatus, Golgi stack
Cell surface
Also localized on the cell surface.
PTM
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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