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Mouse Anti-SULT1C4 Recombinant Antibody (CBXS-5026) (CBMAB-S2248-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5026
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
SULT1C4 (AAH58861.1, 1 a.a.-102 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sulfotransferase Family 1C Member 4
Introduction
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds.
Entrez Gene ID
27233
UniProt ID
O75897
Alternative Names
SULT1C; SULT1C2
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2) (PubMed:17425406, PubMed:28222028, PubMed:9852044, PubMed:26948952).
Mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines (PubMed:26948952).
Biological Process
Biological Process 3'-phosphoadenosine 5'-phosphosulfate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process doxorubicin metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ethanol catabolic processManual Assertion Based On ExperimentIDA:CAFA
Biological Process flavonoid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sulfationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process xenobiotic metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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