Mouse Anti-SUMO Recombinant Antibody (6F2) (CBMAB-0581-LY)

SUMO

Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Probably by sumoylating bet-1, prevents muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression. Plays a role in the attenuation of the let-60/ras pathway.

smt3; sumo

Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (PubMed:11806825).
Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction (PubMed:11806825, PubMed:25475837).
Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17 (PubMed:15107848, PubMed:16701625).
Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates (PubMed:15466489, PubMed:15689373, PubMed:15990876, PubMed:24349540).
Probably by sumoylating bet-1, prevents muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression (PubMed:24285704).
Plays a role in the attenuation of the let-60/ras pathway (PubMed:24349540, PubMed:24285704).
Plays a role in male tail tip morphogenesis (PubMed:21408209).
Plays a role in the mitochondrial stress response with its covalent attachment to transcription factors dve-1 and afts-1 negatively regulating the mitochondrial unfolded protein response (PubMed:30642431).

Biological Process embryo development ending in birth or egg hatchingManual Assertion Based On ExperimentIMP:WormBase
Biological Process mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:WormBase
Biological Process mitotic sister chromatid separationManual Assertion Based On ExperimentIMP:WormBase
Biological Process multicellular organismal locomotionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process muscle cell cellular homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:WormBase
Biological Process nematode larval developmentManual Assertion Based On ExperimentIMP:WormBase
Biological Process positive regulation of nematode male tail tip morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to chromosomeManual Assertion Based On ExperimentIMP:WormBase
Biological Process protein sumoylationManual Assertion Based On ExperimentIMP:WormBase
Biological Process regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of protein stabilityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process synaptonemal complex disassemblyManual Assertion Based On ExperimentIMP:WormBase

Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, spindle
Chromosome
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
At the first embryonic mitotic division, enriched in the nucleus and released to the cytoplasm when the nuclear envelope breaks down at the start of mitosis. During mitosis, localizes to the metaphase plate and to the centrosomal region. Also localizes to segregating chromosomes at the beginning of anaphase. At late anaphase and telophase, observed in the spindle midzone and in the two daughter nuclei.

Cleavage of precursor form by ulp-1 is necessary for function.