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Mouse Anti-SUN2 Recombinant Antibody (CBXS-3739) (CBMAB-S1014-CQ)

This product is a mouse antibody that recognizes SUN2. The antibody CBXS-3739 can be used for immunoassay techniques such as: WB, IF.
See all SUN2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-3739
Application
WB, IF

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sad1 And UNC84 Domain Containing 2
Introduction
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity.
Entrez Gene ID
Human25777
Mouse223697
Rat315135
UniProt ID
HumanQ9UH99
MouseQ8BJS4
RatD3ZTT7
Alternative Names
UNC84B
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
Biological Process
Biological Process centrosome localizationISS:UniProtKB
Biological Process meiotic cell cycleIEA:UniProtKB-KW
Biological Process mitotic spindle organizationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process nuclear envelope organizationManual Assertion Based On ExperimentIGI:MGI
Biological Process nuclear matrix anchoring at nuclear membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process nuclear migrationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process nuclear migration along microfilamentISS:UniProtKB
Biological Process positive regulation of cell migrationISS:UniProtKB
Cellular Location
Nucleus inner membrane
Nucleus envelope
Endosome membrane
Topology
Nuclear: 1-212
Helical: 213-233
Perinuclear space: 234-717
PTM
The disulfide bond with SYNE2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction. The disulfide bond is proposed to be conserved in LINC complexes involved in force transmission.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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