Sign in or Register   Sign in or Register
  |  

Mouse Anti-SUPT4H1 Recombinant Antibody (CBXS-4679) (CBMAB-S1914-CQ)

This product is a mouse antibody that recognizes SUPT4H1. The antibody CBXS-4679 can be used for immunoassay techniques such as: Dot, WB.
See all SUPT4H1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4679
Antibody Isotype
IgG2b
Application
Dot, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
suppressor of Ty 4 homolog 1 (S. cerevisiae)
Introduction
This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
6827
UniProt ID
P63272
Alternative Names
SPT4; SPT4H; SUPT4H; Supt4a
Function
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
Biological Process
Biological Process chromatin organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA processingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of DNA-templated transcription, elongationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transcription elongation by RNA polymerase IIIEA:Ensembl
Biological Process positive regulation of DNA-templated transcription, elongationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of transcription elongation by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transcription elongation by RNA polymerase II promoterManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SUPT4H1 Recombinant Antibody (CBXS-4679)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare