Rabbit Anti-SURF4 Recombinant Antibody (CBXS-1423) (CBMAB-S4281-CQ)

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Basic Information

Host Animal
Rabbit
Clone
CBXS-1423
Application
WB, FC, IF
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Surfeit 4
Introduction
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
Human6836
Mouse20932
Rat619346
UniProt ID
HumanO15260
MouseQ64310
RatQ7TP91
Alternative Names
ERV29
Function
Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:30251625, PubMed:29643117, PubMed:33186557).
Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:29643117, PubMed:33186557).
Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed:33186557).
Promotes the secretion of PCSK9 (PubMed:30251625).
Also mediates the efficient secretion of erythropoietin (EPO) (PubMed:32989016).
May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (PubMed:18287528).
Biological Process
Biological Process Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process lipid homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process lipoprotein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of organelle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of lipid transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi apparatus membrane
Cycles between the endoplasmic reticulum and the Golgi.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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