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Mouse Anti-SV2B Recombinant Antibody (CBXS-4452) (CBMAB-S1694-CQ)

This product is a mouse antibody that recognizes SV2B. The antibody CBXS-4452 can be used for immunoassay techniques such as: ELISA.
See all SV2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4452
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
SV2B (NP_055663, 417 a.a.-476 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SV2B
Introduction
This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients.
Entrez Gene ID
9899
UniProt ID
Q7L1I2
Alternative Names
HsT19680
Function
Probably plays a role in the control of regulated secretion in neural and endocrine cells.
(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119).
Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1
Biological Process
Biological Process chemical synaptic transmissionIEA:InterPro
Biological Process neurotransmitter transportIEA:UniProtKB-KW
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cytoplasmic vesicle, secretory vesicle, acrosome
Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (By similarity).
Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity).
Topology
Cytoplasmic: 1-108
Helical: 109-129
Extracellular: 130-148
Helical: 149-169
Cytoplasmic: 170-182
Helical: 183-203
Extracellular: 204-205
Helical: 206-226
Cytoplasmic: 227-237
Helical: 238-258
Extracellular: 259-277
Helical: 278-298
Cytoplasmic: 299-390
Helical: 391-411
Extracellular: 412-535
Helical: 536-556
Cytoplasmic: 557-565
Helical: 566-586
Extracellular: 587-592
Helical: 593-613
Cytoplasmic: 614-626
Helical: 627-649
Extracellular: 650-653
Helical: 654-672
Cytoplasmic: 673-683
PTM
N-glycosylated.
The N-terminal cytoplasmic domain is phosphorylated by CK1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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