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Mouse Anti-SYCE1 Recombinant Antibody (CBXS-0896) (CBMAB-S3815-CQ)

This product is a mouse antibody that recognizes SYCE1. The antibody CBXS-0896 can be used for immunoassay techniques such as: S-ELISA, WB, ELISA.
See all SYCE1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0896
Antibody Isotype
IgG2a, κ
Application
S-ELISA, WB, ELISA

Basic Information

Immunogen
SYCE1 (NP_963858.1, 1 a.a.-190 a.a) Full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
synaptonemal complex central element protein 1
Introduction
This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
93426
UniProt ID
Q8N0S2
Alternative Names
C10orf94; CT76; POF12; SPGF15
Function
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.
Biological Process
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process synaptonemal complex assemblyIC:BHF-UCL1 Publication
Cellular Location
Nucleus
Chromosome
Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements.
Involvement in disease
Premature ovarian failure 12 (POF12):
An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Spermatogenic failure, 15 (SPGF15):
An infertility disorder caused by spermatogenesis defects and characterized by non-obstructive azoospermia due to complete meiotic maturation arrest. SPGF15 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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