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Mouse Anti-SYNE2 Recombinant Antibody (CBXS-2210) (CBMAB-S4972-CQ)

This product is a mouse antibody that recognizes SYNE2. The antibody CBXS-2210 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SYNE2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBXS-2210
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SYNE2
Introduction
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Mouse319565
Rat366669
UniProt ID
MouseQ6ZWQ0
RatA0A8I5ZNW6
Alternative Names
6820443O06Rik; AW546258; Cpfl8; D12Ertd777e; KASH2; NUA; Nesp2g; dice; mKIAA1011
Function
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis.
Biological Process
Biological Process centrosome localizationIMP:UniProtKB1 Publication
Biological Process nuclear migrationIMP:UniProtKB1 Publication
Biological Process nuclear migration along microfilamentISS:UniProtKB
Biological Process nucleokinesis involved in cell motility in cerebral cortex radial glia guided migrationIEA:Ensembl
Biological Process positive regulation of cell migrationISS:UniProtKB
Biological Process regulation of cilium assemblyIEA:Ensembl
Cellular Location
Nucleus outer membrane
Sarcoplasmic reticulum membrane
Cell membrane
Cytoplasm, cytoskeleton
Mitochondrion
Nucleus, nucleoplasm
Cytoplasm, myofibril, sarcomere, Z line
Different isoform patterns are found in the different compartments of the cell. The isoforms having the C-terminal transmembrane span can be found in several organellar membranes like the nuclear envelope, the sarcoplasmic reticulum of myoblasts, or the lamellipodia and focal adhesions at the cell membrane. The largest part of the outer nuclear membrane-associated protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells. Shorter soluble isoforms can be found in the cytoplasm and within the nucleus.
Isoform 8
Cell junction, focal adhesion
In U2OS cells.
Involvement in disease
Emery-Dreifuss muscular dystrophy 5, autosomal dominant (EDMD5):
A form of Emery-Dreifuss muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.
Topology
Cytoplasmic: 1-6834
Helical: 6835-6855
Perinuclear space: 6856-6885
PTM
The disulfid bond with SUN2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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