Sign in or Register   Sign in or Register
  |  

Mouse Anti-SYNJ1 Monoclonal Antibody (AC1) (CBMAB-1582-YC)

Provided herein is a mouse monoclonal antibody against Rat SYNJ1. The antibody, clone AC1, can be used for immunoassay techniques, such as ICC, IF, IHC-Fr, IP and WB.
See all SYNJ1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
AC1
Antibody Isotype
IgG
Application
ICC, IF, IHC-Fr, IP, WB

Basic Information

Immunogen
Recombinant fragment corresponding to C terminal amino acids 1156-1286 of Rat Synaptojanin
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Synaptojanin 1
Introduction
SYNJ1 is a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking.
Entrez Gene ID
85238
UniProt ID
Q62910
Alternative Names
EIEE53; INPP5G; PARK20
Function
Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:27435091).
Has a role in clathrin-mediated endocytosis (By similarity).
Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity).
Biological Process
Biological Process brain developmentIBA:GO_Central1 Publication
Biological Process inositol phosphate dephosphorylationISS:ParkinsonsUK-UCL
Biological Process inositol phosphate metabolic processTAS:Reactome
Biological Process learningIMP:ParkinsonsUK-UCL1 Publication
Biological Process membrane organizationTAS:Reactome
Biological Process neurotransmitter transportISS:ParkinsonsUK-UCL
Biological Process phosphatidylinositol biosynthetic processTAS:Reactome
Biological Process phosphatidylinositol dephosphorylationIDA:ParkinsonsUK-UCL1 Publication
Biological Process phosphatidylinositol metabolic processISS:ParkinsonsUK-UCL
Biological Process positive regulation of endosome organizationIMP:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of gliogenesisIEA:Ensembl
Biological Process positive regulation of receptor-mediated endocytosisIEA:Ensembl
Biological Process response to cytokineIEA:Ensembl
Biological Process response to retinoic acidIEA:Ensembl
Biological Process synaptic vesicle endocytosisIGI:ParkinsonsUK-UCL1 Publication
Biological Process synaptic vesicle primingISS:ParkinsonsUK-UCL
Biological Process synaptic vesicle transportISS:ParkinsonsUK-UCL
Biological Process synaptic vesicle uncoatingISS:ParkinsonsUK-UCL
Cellular Location
Cytoplasm, perinuclear region
Involvement in disease
Parkinson disease 20, early-onset (PARK20):
An early-onset form of Parkinson disease, a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK20 is characterized by young adult-onset of parkinsonism. Additional features may include seizures, cognitive decline, abnormal eye movements, and dystonia.
Developmental and epileptic encephalopathy 53 (DEE53):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE53 inheritance is autosomal recessive.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SYNJ1 Monoclonal Antibody (AC1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare