Mouse Anti-SYT12 Monoclonal Antibody (S277-7) (CBMAB-1594-YC)

Name: Mouse Anti-SYT12 Monoclonal Antibody (S277-7)
SKU: CBMAB-1594-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

S277-7

Application

ICC, IF, IHC, WB

Immunogen

Fusion protein aa168-255 (Cytoplasmic C2A domain) of mouse Synaptotagmin-12.

Specificity

Mouse, Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Synaptotagmin 12

Introduction

SYT12 is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells.

Entrez Gene ID

Human	91683
Mouse	171180

UniProt ID

Human	Q8IV01
Mouse	Q920N7

Alternative Names

SYT11; sytXII

Function

Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity).
Unlike other synaptotagmins, it does not bind Ca2+ or phospholipids (By similarity).
Essential for mossy-fiber long-term potentiation in the hippocampus (By similarity).

Biological Process

Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process long-term synaptic potentiationIEA:Ensembl
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process regulation of neurotransmitter secretionIEA:InterPro
Biological Process spontaneous exocytosis of neurotransmitterIEA:Ensembl
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication

Cellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane

Topology

Vesicular: 1-18
Helical: 19-39
Cytoplasmic: 40-421

PTM

Phosphorylation of Ser-97 is required for mossy-fiber long-term potentiation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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