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Mouse Anti-SYT12 Monoclonal Antibody (S277-7) (CBMAB-1594-YC)

Provided herein is a mouse monoclonal antibody against Mouse SYT12. The antibody, clone S277-7, can be used for immunoassay techniques, such as ICC, IF, IHC and WB.
See all SYT12 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
S277-7
Antibody Isotype
IgG1
Application
ICC, IF, IHC, WB

Basic Information

Immunogen
Fusion protein aa168-255 (Cytoplasmic C2A domain) of mouse Synaptotagmin-12.
Specificity
Mouse, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Synaptotagmin 12
Introduction
SYT12 is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells.
Entrez Gene ID
Human91683
Mouse171180
UniProt ID
HumanQ8IV01
MouseQ920N7
Alternative Names
SYT11; sytXII
Function
Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity).
Unlike other synaptotagmins, it does not bind Ca2+ or phospholipids (By similarity).
Essential for mossy-fiber long-term potentiation in the hippocampus (By similarity).
Biological Process
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process long-term synaptic potentiationIEA:Ensembl
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process regulation of neurotransmitter secretionIEA:InterPro
Biological Process spontaneous exocytosis of neurotransmitterIEA:Ensembl
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Topology
Vesicular: 1-18
Helical: 19-39
Cytoplasmic: 40-421
PTM
Phosphorylation of Ser-97 is required for mossy-fiber long-term potentiation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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