SYT12

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.

Full Name

Synaptotagmin 12

Function

Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity).
Unlike other synaptotagmins, it does not bind Ca2+ or phospholipids (By similarity).
Essential for mossy-fiber long-term potentiation in the hippocampus (By similarity).

Biological Process

Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process long-term synaptic potentiationIEA:Ensembl
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process regulation of neurotransmitter secretionIEA:InterPro
Biological Process spontaneous exocytosis of neurotransmitterIEA:Ensembl
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication

Cellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane

Topology

Vesicular: 1-18
Helical: 19-39
Cytoplasmic: 40-421

PTM

Phosphorylation of Ser-97 is required for mossy-fiber long-term potentiation.