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Mouse Anti-SYT2 Recombinant Antibody (1G10) (CBMAB-A8819-LY)


See all SYT2 antibodies
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SYT2 (NP_796376, 311 a.a. ~ 418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
synaptotagmin II
Introduction
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).[supplied by OMIM
Entrez Gene ID
127833
UniProt ID
Q8N9I0
Alternative Names
SytII
Function
Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity).
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity).
Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
Biological Process calcium ion-regulated exocytosis of neurotransmitterIBA:GO_Central1 Publication
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process positive regulation of dendrite extensionIDA:UniProtKB1 Publication
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process synaptic vesicle endocytosisIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane
Involvement in disease
Myasthenic syndrome, congenital, 7A, presynaptic, and distal motor neuropathy, autosomal dominant (CMS7A):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. CMS7A is an autosomal dominant, presynaptic disorder resembling Lambert-Eaton myasthenic syndrome. Affected individuals have a variable degree of proximal and distal limb weakness, muscle fatigue that improves with rest, mild gait difficulties, and reduced or absent deep tendon reflexes.
Myasthenic syndrome, congenital, 7B, presynaptic, autosomal recessive (CMS7B):
An autosomal recessive form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. CMS7B is characterized by defects at the pre-synaptic neuromuscular junction and severe generalized muscle weakness apparent from birth. Decreased fetal movements may be apparent in utero. Affected infants have generalized hypotonia, head lag, and facial muscle weakness with ptosis. Some patients may have respiratory involvement.
Topology
Vesicular: 1-62
Helical: 63-83
Cytoplasmic: 84-419
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For research use only. Not intended for any clinical use.

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