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Mouse Anti-SYT6 Recombinant Antibody (S270-47) (CBMAB-S0024-CQ)

This product is a mouse antibody that recognizes SYT6. The antibody S270-47 can be used for immunoassay techniques such as: WB, IF.
See all SYT6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S270-47
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Fusion protein amino acids 246-333 (Cytoplasmic C2A domain) of mouse Synaptotagmin-6
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Synaptotagmin 6
Introduction
The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
Human148281
Mouse54524
Rat60565
UniProt ID
HumanQ5T7P8
MouseQ9R0N8
RatQ62746
Alternative Names
sytVI
Function
May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. May mediate Ca2+-regulation of exocytosis in acrosomal reaction in sperm (By similarity).
Biological Process
Biological Process acrosomal vesicle exocytosisIMP:BHF-UCL1 Publication
Biological Process calcium-ion regulated exocytosisIBA:GO_Central1 Publication
Biological Process cellular response to calcium ionIBA:GO_Central1 Publication
Biological Process regulation of calcium ion-dependent exocytosisIBA:GO_Central1 Publication
Biological Process regulation of dopamine secretionIBA:GO_Central1 Publication
Biological Process vesicle-mediated transportIBA:GO_Central1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Isoform 1
Membrane
Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (By similarity).
Isoform 2
Cytoplasm, cytosol
Cell membrane
Topology
Vesicular: 1-59
Helical: 60-80
Cytoplasmic: 81-510
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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