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Mouse Anti-SYVN1 Recombinant Antibody (CBXS-5111) (CBMAB-S2329-CQ)

This product is a mouse antibody that recognizes SYVN1. The antibody CBXS-5111 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all SYVN1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-5111
Application
WB, IP, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Synoviolin 1
Introduction
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.
Entrez Gene ID
Human84447
Mouse74126
Rat361712
UniProt ID
HumanQ86TM6
MouseQ9DBY1
RatF7FG68
Alternative Names
DER3; HRD1
Function
E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28827405).
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558).
Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218).
Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702).
Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity).
During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity).
Biological Process
Biological Process endoplasmic reticulum mannose trimmingTAS:Reactome
Biological Process ERAD pathwayIDA:ParkinsonsUK-UCL1 Publication
Biological Process immature B cell differentiationISS:UniProtKB
Biological Process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayIDA:ParkinsonsUK-UCL2 Publications
Biological Process protein K48-linked ubiquitinationIDA:ParkinsonsUK-UCL1 Publication
Biological Process protein stabilizationIMP:ParkinsonsUK-UCL1 Publication
Biological Process protein ubiquitinationIDA:ParkinsonsUK-UCL2 Publications
Biological Process retrograde protein transport, ER to cytosolIMP:ParkinsonsUK-UCL1 Publication
Biological Process ubiquitin-dependent ERAD pathwayIDA:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic processIDA:ParkinsonsUK-UCL2 Publications
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
In certain aggressive cases of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL), plays a role in the degradation of misfolded N-terminal mutated PRDM1 proteins.
Topology
Cytoplasmic: 1-4
Helical: 5-25
Lumenal: 26-41
Helical: 42-62
Cytoplasmic: 63-98
Helical: 99-119
Lumenal: 120-140
Helical: 141-161
Cytoplasmic: 162-169
Helical: 170-190
Lumenal: 191-224
Helical: 225-245
Cytoplasmic: 246-617
PTM
Not N-glycosylated.
Auto-ubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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