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Rabbit Anti-TAB3 Recombinant Antibody (CBYJT-1758) (CBMAB-T0819-YJ)

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Basic Information

Host Animal
Rabbit
Clone
CBYJT-1758
Application
WB
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
TAB3 Gene(Protein Coding) TGF-Beta Activated Kinase 1 And MAP3K7 Binding Protein 3
Introduction
The product of this gene functions in the NF-kappaB signal transduction pathway. TAB3, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor.
Entrez Gene ID
Human257397
Mouse66724
Rat317546
UniProt ID
HumanQ8N5C8
MouseQ571K4
RatF1M1D2
Alternative Names
TGF-Beta Activated Kinase 1 And MAP3K7 Binding Protein 3; Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3; TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 3; TGF-Beta-Activated Kinase 1-Binding Protein 3; NF-Kappa-B-Activating Protein 1; TAK1-Binding Protein 3; MAP3K7IP3
Function
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122).
Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158122).
The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:22158122).4 Publications
Isoform 2
May be an oncogenic factor.
Biological Process
Biological Process negative regulation of autophagyTAS:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingIDA:UniProtKB2 Publications
Cellular Location
cytosol
endosome membrane
extracellular exosome
plasma membrane
PTM
Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.
Degraded in a lysosome-dependent manner following interactiuon with TRIM38.
Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.
(Microbial infection) Methylated at Cys-692 by enteropathogenic E.coli protein NleE or S.flexneri protein OspZ: methylation disrupts zinc-binding and ability to bind 'Lys-63'-linked ubiquitin, leading to NF-kappa-B inactivation.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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