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Mouse Anti-TADA3L Recombinant Antibody (3H3) (CBMAB-A8836-LY)

The product is antibody recognizes TADA3L. The antibody 3H3 immunoassay techniques such as: WB, ELISA.
See all TADA3L antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TADA3L (AAH13433, 1 a.a. ~ 432 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TADA3
Introduction
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq]
Entrez Gene ID
10474
UniProt ID
O75528
Alternative Names
ADA3; FLJ20221; FLJ21329; hADA3
Function
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Biological Process
Biological Process histone acetylationIC:ComplexPortal1 Publication
Biological Process histone H3 acetylationIDA:UniProtKB1 Publication
Biological Process histone H3-K14 acetylationIDA:ComplexPortal1 Publication
Biological Process intracellular estrogen receptor signaling pathwayTAS:UniProtKB1 Publication
Biological Process mitotic cell cycleIEA:Ensembl
Biological Process monoubiquitinated histone deubiquitinationIDA:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitinationIDA:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB1 Publication
Biological Process positive regulation of gene expressionIMP:UniProtKB1 Publication
Biological Process regulation of cell cycleIMP:ComplexPortal1 Publication
Biological Process regulation of cell divisionIDA:ComplexPortal1 Publication
Biological Process regulation of DNA repairIC:ComplexPortal2 Publications
Biological Process regulation of DNA-templated transcriptionIMP:ComplexPortal1 Publication
Biological Process regulation of embryonic developmentIC:ComplexPortal
Biological Process regulation of histone deacetylationIMP:ComplexPortal1 Publication
Biological Process regulation of protein phosphorylationIEA:Ensembl
Biological Process regulation of protein stabilityIEA:Ensembl
Biological Process regulation of RNA splicingIC:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase IIIDA:ComplexPortal2 Publications
Biological Process regulation of tubulin deacetylationIMP:ComplexPortal1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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