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Mouse Anti-TAF13 Recombinant Antibody (304C2a) (CBMAB-T0905-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAF13 (TATA-Box Binding Protein Associated Factor 13). The antibody can be used for immunoassay techniques, such as WB, Dot.
See all TAF13 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
304C2a
Antibody Isotype
IgG2b
Application
WB, Dot

Basic Information

Immunogen
Recombinant fragment of human TAF13, from a sequence which includes most of the molecule minus the N terminus.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
Introduction
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF13 is a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11.
Entrez Gene ID
6884
UniProt ID
Q15543
Alternative Names
TATA-Box Binding Protein Associated Factor 13; TAF13 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 18kDa; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, K, 18kD; Transcription Initiation Factor TFIID 18 KDa Subunit; TAF(II)18; TAFII-18
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473, PubMed:9695952).
TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).
The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).
TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes (PubMed:33795473).
Biological Process
Biological Process DNA-templated transcription initiationNAS:UniProtKB1 Publication
Biological Process mRNA transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process positive regulation of transcription initiation by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein phosphorylationIDA:ComplexPortal1 Publication
Biological Process RNA polymerase II preinitiation complex assemblyIPI:ComplexPortal1 Publication
Biological Process transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process transcription initiation at RNA polymerase II promoterIC:UniProtKB1 Publication
Cellular Location
Nucleus
Involvement in disease
Intellectual developmental disorder, autosomal recessive 60 (MRT60):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT60 patients display mild intellectual disability, delayed psychomotor development, learning difficulties, and poor overall growth with variable microcephaly.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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