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Mouse Anti-TAF2 Recombinant Antibody (CBYJT-1864) (CBMAB-T0932-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TAF2 (TATA-Box Binding Protein Associated Factor 2). The antibody can be used for immunoassay techniques, such as WB.
See all TAF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1864
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
TAF2 antibody was raised in Mouse using Human recombinant protein fragment corresponding to amino acids 782-1121 of human TAF2 produced in E. coli as the immunogen
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 782-1121

Target

Full Name
TATA-Box Binding Protein Associated Factor 2
Introduction
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF2 is one of the larger subunits of TFIID that is stably associated with the TFIID complex. TAF2 contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.
Entrez Gene ID
6873
UniProt ID
Q6P1X5
Alternative Names
TATA-Box Binding Protein Associated Factor 2; TAF2 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 150kDa; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, B, 150kD; Transcription Initiation Factor TFIID 150 KDa Subunit; RNA Polymerase II TBP-Associated Factor Subunit B; 150 KDa Cofactor Of Initiator Function; TBP-Associated Factor 150 KDa; TAF(II)150
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).
TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).
The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:9418870, PubMed:9774672).
TAF2 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF1 (PubMed:9774672, PubMed:33795473).
Biological Process
Biological Process G2/M transition of mitotic cell cycleIMP:UniProtKB1 Publication
Biological Process histone H3 acetylationIDA:ComplexPortal1 Publication
Biological Process monoubiquitinated histone deubiquitinationIDA:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitinationIDA:ComplexPortal1 Publication
Biological Process mRNA transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcriptionIC:ComplexPortal1 Publication
Biological Process positive regulation of transcription initiation by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein phosphorylationIDA:ComplexPortal1 Publication
Biological Process regulation of DNA repairIC:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process response to organic cyclic compoundIEA:Ensembl
Biological Process RNA polymerase II preinitiation complex assemblyIPI:ComplexPortal1 Publication
Biological Process transcription initiation at RNA polymerase II promoterIDA:UniProtKB1 Publication
Cellular Location
Nucleus
Involvement in disease
Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity (NEDFCF):
An autosomal recessive disorder characterized by impaired intellectual development, microcephaly, delayed psychomotor development, pyramidal signs, thin corpus callosum, and foot deformity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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