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Recombinant Mouse Anti-TAF3 Recombinant Antibody (2F5) (CBMAB-XB1093-YC)

Provided herein is a Mouse Recombinant Antibody against TATA-Box Binding Protein Associated Factor 3. The antibody can be used for immunoassay techniques, such as ELISA, IHC, IP, WB.
See all TAF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
2F5
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, IP, WB

Basic Information

Immunogen
Synthetic peptide QFPQPGSKDAEERKEYIPDY corresponding to amino acids 108-127 of human TAF3
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TATA-Box Binding Protein Associated Factor 3
Introduction
The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors.
Entrez Gene ID
Human83860
Mouse209361
UniProt ID
HumanQ5VWG9
MouseQ5HZG4
Alternative Names
TAF140; TAFII140; TAFII-140
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).
TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).
The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473).
The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473).
TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473).
Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666).
The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666).
Biological Process
Biological Process maintenance of protein location in nucleusIDA:HGNC-UCL1 Publication
Biological Process mRNA transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process negative regulation of DNA-binding transcription factor activityIDA:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process positive regulation of transcription initiation by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein phosphorylationIDA:ComplexPortal1 Publication
Biological Process RNA polymerase II preinitiation complex assemblyIPI:ComplexPortal1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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