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Recombinant Mouse Anti-TAF7 Recombinant Antibody (2C7) (CBMAB-XB1099-YC)

Provided herein is a Mouse Recombinant Antibody against TATA-Box Binding Protein Associated Factor 7. The antibody can be used for immunoassay techniques, such as ELISA, IHC, IP, WB.
See all TAF7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
2C7
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, IP, WB

Basic Information

Immunogen
Recombinant human TAF7 protein
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Introduction
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators.
Entrez Gene ID
Human6879
Mouse24074
UniProt ID
HumanQ15545
MouseQ9R1C0
Alternative Names
TATA-Box Binding Protein Associated Factor 7; TAF7 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 55kDa; TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, F, 55kD; RNA Polymerase II TBP-Associated Factor Subunit F; TAF(II)55; TAFII-55; TAFII55;
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473).
TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473).
The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:10438527).
TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 (PubMed:33795473).
Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) (PubMed:10438527).
Biological Process
Biological Process DNA-templated transcription initiationIDA:UniProtKB1 Publication
Biological Process histone H3 acetylationIDA:ComplexPortal1 Publication
Biological Process intracellular estrogen receptor signaling pathwayIEA:Ensembl
Biological Process monoubiquitinated histone deubiquitinationIDA:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitinationIDA:ComplexPortal1 Publication
Biological Process mRNA transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process negative regulation of DNA-templated transcriptionIDA:UniProtKB3 Publications
Biological Process negative regulation of histone acetylationIDA:UniProtKB1 Publication
Biological Process negative regulation of histone H4 acetylationIDA:CACAO1 Publication
Biological Process negative regulation of MHC class I biosynthetic processIDA:CACAO1 Publication
Biological Process negative regulation of MHC class II biosynthetic processIMP:CACAO1 Publication
Biological Process negative regulation of protein kinase activityIDA:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcriptionIC:ComplexPortal1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process positive regulation of transcription initiation by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process protein phosphorylationIDA:ComplexPortal1 Publication
Biological Process regulation of DNA repairIC:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase IIIDA:ComplexPortal1 Publication
Biological Process RNA polymerase II preinitiation complex assemblyIPI:ComplexPortal1 Publication
Biological Process spermine transportISS:GO_Central
Biological Process transcription by RNA polymerase IIIDA:UniProtKB1 Publication
Biological Process transcription initiation at RNA polymerase II promoterIDA:UniProtKB2 Publications
Cellular Location
Nucleus
PTM
Phosphorylated by CIITA. Phosphorylation at Ser-264 by TAF1 in early G1 phase disrupts binding to TAF1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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