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Mouse Anti-TALDO1 Recombinant Antibody (CBYJT-1932) (CBMAB-T1017-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TALDO1 (Transaldolase 1). The antibody can be used for immunoassay techniques, such as WB, IHC.
See all TALDO1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1932
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human TALDO1 (NP_006746) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transaldolase 1
Introduction
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. TALDO1 is thought to be involved in multiple sclerosis.
Entrez Gene ID
6888
UniProt ID
P37837
Alternative Names
Transaldolase 1; EC 2.2.1.2; TALDOR; TAL; Testicular Secretory Protein Li 56; Dihydroxyacetone Transferase
Function
Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate (PubMed:8955144, PubMed:18687684).
Not only acts as a pentose phosphate pathway enzyme, but also affects other metabolite pathways by altering its subcellular localization between the nucleus and the cytoplasm (By similarity).
Biological Process
Biological Process carbohydrate metabolic processTAS:ProtInc1 Publication
Biological Process fructose 6-phosphate metabolic processIEA:Ensembl
Biological Process glyceraldehyde-3-phosphate metabolic processIEA:Ensembl
Biological Process pentose-phosphate shunt, non-oxidative branchIBA:GO_Central1 Publication
Cellular Location
Isoform 1
Nucleus
Cytoplasm
Shuttles between the nucleus and the cytoplasm. Actively transported into the nucleus in an importin alpha/beta-dependent manner. Exported into the cytoplasm by CRM1.
Isoform 2
Cytoplasm
Imported into the nucleus when incorporated in isoform 1/isoform 2 homodimer.
Involvement in disease
Transaldolase deficiency (TALDOD):
An inborn error of the pentose phosphate pathway resulting in early-onset multisystem disease. Clinical features include growth retardation, dysmorphic features, cutis laxa, congenital heart disease, hepatosplenomegaly, telangiectases of the skin, pancytopenia, and bleeding tendency.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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