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Mouse Anti-TARBP1 Recombinant Antibody (CBYJT-1981) (CBMAB-T1069-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TARBP1 (TAR (HIV-1) RNA Binding Protein 1). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TARBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1981
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TAR (HIV-1) RNA Binding Protein 1
Introduction
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined.
Entrez Gene ID
6894
UniProt ID
Q13395
Alternative Names
TAR (HIV-1) RNA Binding Protein 1; TAR RNA-Binding Protein Of 185 KDa; TAR RNA-Binding Protein 1; TRP-185; TRP185; TRM3; TRNA Methyltransferase 3 Homolog (S. Cerevisiae)
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs.
(Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II (PubMed:7638159, PubMed:8626763, PubMed:8846792).
Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA (PubMed:7638159, PubMed:8626763, PubMed:8846792).
Biological Process
Biological Process regulation of transcription by RNA polymerase IITAS:ProtInc1 Publication
Biological Process tRNA methylationIBA:GO_Central1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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