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Mouse Anti-TARS Recombinant Antibody (CBYJT-2007) (CBMAB-T1098-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TARS (Threonyl-TRNA Synthetase). The antibody can be used for immunoassay techniques, such as FC, ICC, WB.
See all TARS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2007
Antibody Isotype
IgG2a
Application
FC, ICC, WB

Basic Information

Immunogen
Partial sequence of recombinant full-length protein to human tRNA Synthetase, Threonyl (TARS)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA, 40% Glycerol
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
threonyl-tRNA synthetase
Introduction
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution.
Entrez Gene ID
6897
UniProt ID
P26639
Alternative Names
Threonyl-TRNA Synthetase; Threonine TRNA Ligase 1, Cytoplasmic; EC 6.1.1.3; ThrRS; Threonyl-TRNA Synthetase, Cytoplasmic; Threonine--TRNA Ligase, Cytoplasmic
Function
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204).
Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity).
Biological Process
Threonyl-tRNA aminoacylation
Cellular Location
Cytoplasm
Involvement in disease
Trichothiodystrophy 7, non-photosensitive (TTD7):
A form of trichothiodystrophy, a disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder. TTD7 patients do not manifest cutaneous photosensitivity. They have cysteine- and threonine-deficient hair with alternating light and dark 'tiger-tail' banding pattern observed under polarization microscopy. Inheritance pattern is autosomal recessive.
PTM
ISGylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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