Sign in or Register   Sign in or Register
  |  

Mouse Anti-TASP1 Recombinant Antibody (CBYJT-2010) (CBMAB-T1102-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TASP1 (Taspase 1). The antibody can be used for immunoassay techniques, such as WB.
See all TASP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2010
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human TASP1 (NP_060184) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
taspase, threonine aspartase, 1
Introduction
TASP1 is an endopeptidase that cleaves specific substrates following aspartate residues. TASP1 undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor.
Entrez Gene ID
55617
UniProt ID
Q9H6P5
Alternative Names
Taspase 1; C20orf13; Chromosome 20 Open Reading Frame 13; Threonine Aspartase 1; Threonine Aspartase; EC 3.4.25.-; DJ585I14.2; Taspase-1
Function
Protease responsible for KMT2A/MLL1 processing and activation (PubMed:14636557).
It also activates KMT2D/MLL2 (By similarity).
Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity) (PubMed:14636557).
Biological Process
Biological Process positive regulation of DNA-templated transcriptionIMP:UniProtKB1 Publication
Biological Process protein maturationIBA:GO_Central1 Publication
Biological Process proteolysisIMP:CACAO1 Publication
Cellular Location
Cytoplasm
Involvement in disease
Suleiman-El-Hattab syndrome (SULEHS):
An autosomal recessive syndrome characterized by global developmental delay with poor expressive language, poor fine motor skills and hypotonia, microcephaly, feeding difficulties with failure to thrive, recurrent respiratory infections, cardiovascular malformations, cryptorchidism, happy demeanor, and facial dysmorphism. Distinctive facial features are excessive forehead hair, arched and thick eyebrows with synophrys, epicanthus, hypertelorism, thick eyelids with periorbital fullness, broad nasal bridge, long and smooth philtrum, thin upper lip, and low set prominent ears.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TASP1 Recombinant Antibody (CBYJT-2010)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare