Mouse Anti-Tau Recombinant Antibody (PHF13.6) (CBMAB-0477CQ)

Name: Mouse Anti-Tau Recombinant Antibody (PHF13.6)
SKU: CBMAB-0477CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

PHF13.6

Application

WB, ELISA

Immunogen

Purified human PHF-Tau preparation

Specificity

Human, Dog, Rat, Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Tau

Introduction

The microtubule-associated proteins (MAPs) coassemble with tubulin into microtubules in vitro. Microtubule-associated protein tau appears to be enriched in axons. This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. Andreadis et al. (1992) found that the tau isoforms that predominate in human brain are encoded by 11 exons. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Entrez Gene ID

Human	4137
Mouse	17762
Rat	29477
Dog	480488

UniProt ID

Human	P10636
Mouse	P10637
Rat	P19332
Dog	A0A8C0MR30

Alternative Names

TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103

Nadel, C. M., Thwin, A. C., Callahan, M., Lee, K., Connelly, E., Craik, C. S., ... & Gestwicki, J. E. (2023). The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT). Journal of Molecular Biology, 435(11), 168026.

Brandt, R., Trushina, N. I., & Bakota, L. (2020). Much more than a cytoskeletal protein: physiological and pathological functions of the non-microtubule binding region of tau. Frontiers in Neurology, 11, 590059.

Han, X., Sekino, Y., Babasaki, T., Goto, K., Inoue, S., Hayashi, T., ... & Matsubara, A. (2020, June). Microtubule-associated protein tau (MAPT) is a promising independent prognostic marker and tumor suppressive protein in clear cell renal cell carcinoma. In Urologic Oncology: Seminars and Original Investigations (Vol. 38, No. 6, pp. 605-e9). Elsevier.

Sekino, Y., Han, X., Babasaki, T., Goto, K., Inoue, S., Hayashi, T., ... & Matsubara, A. (2020, October). Microtubule-associated protein tau (MAPT) promotes bicalutamide resistance and is associated with survival in prostate cancer. In Urologic Oncology: Seminars and Original Investigations (Vol. 38, No. 10, pp. 795-e1). Elsevier.

Schroeder, C., Grell, J., Hube-Magg, C., Kluth, M., Lang, D., Simon, R., ... & Steurer, S. (2019). Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer. BMC cancer, 19, 1-10.

Barbier, P., Zejneli, O., Martinho, M., Lasorsa, A., Belle, V., Smet-Nocca, C., ... & Landrieu, I. (2019). Role of tau as a microtubule-associated protein: structural and functional aspects. Frontiers in aging neuroscience, 11, 204.

Xu, Y., Zhang, S., & Zheng, H. (2019). The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy, 15(4), 583-598.

Olczak, M., Poniatowski, Ł. A., Niderla-Bielińska, J., Kwiatkowska, M., Chutorański, D., Tarka, S., & Wierzba-Bobrowicz, T. (2019). Concentration of microtubule associated protein tau (mapt) in urine and saliva as a potential biomarker of traumatic brain injury in relationship with blood–brain barrier disruption in postmortem examination. Forensic science international, 301, 28-36.

Melková, K., Zapletal, V., Narasimhan, S., Jansen, S., Hritz, J., Škrabana, R., ... & Žídek, L. (2019). Structure and functions of microtubule associated proteins tau and MAP2c: similarities and differences. Biomolecules, 9(3), 105.

Gaig, C., Ercilla, G., Daura, X., Ezquerra, M., Fernández-Santiago, R., Palou, E., ... & Graus, F. (2019). HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease. Neurology-Neuroimmunology Neuroinflammation, 6(6).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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