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Mouse Anti-TBC1D20 Recombinant Antibody (CBYJT-2039) (CBMAB-T1133-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBC1D20 (TBC1 Domain Family Member 20). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TBC1D20 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
CBYJT-2039
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 289-420 mapping at the C-terminus of Taspase 1 of human origin
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 289-420

Target

Full Name
TBC1 Domain Family Member 20
Introduction
TBC1D20 is a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. TBC1D20 and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of TBC1D20 inhibits replication of the virus and HCV infection. Mutations in TBC1D20 are associated with Warburg micro syndrome 4.
Entrez Gene ID
Human128637
Mouse67231
Rat362237
UniProt ID
HumanQ96BZ9
MouseQ9D9I4
RatQ6AXR1
Alternative Names
TBC1 Domain Family Member 20; C20orf140; Chromosome 20 Open Reading Frame 140; TBC1 Domain Family, Member 20; WARBM4
Function
GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.
Biological Process
Biological Process acrosome assemblyIEA:Ensembl
Biological Process COPII-coated vesicle cargo loadingIMP:UniProtKB1 Publication
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportIMP:UniProtKB1 Publication
Biological Process Golgi organizationIMP:UniProtKB1 Publication
Biological Process lens fiber cell morphogenesisIEA:Ensembl
Biological Process lipid droplet organizationIEA:Ensembl
Biological Process positive regulation by host of viral genome replicationIMP:AgBase1 Publication
Biological Process positive regulation by virus of viral protein levels in host cellIMP:AgBase1 Publication
Biological Process positive regulation of ER to Golgi vesicle-mediated transportIMP:UniProtKB1 Publication
Biological Process positive regulation of GTPase activityIMP:UniProtKB1 Publication
Biological Process seminiferous tubule developmentIEA:Ensembl
Biological Process virion assemblyIMP:UniProtKB1 Publication
Cellular Location
Membrane
Involvement in disease
Warburg micro syndrome 4 (WARBM4):
A form of Warburg micro syndrome, a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe intellectual disability, spastic diplegia, and hypogonadism.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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