Mouse Anti-TBC1D20 Recombinant Antibody (CBYJT-2039) (CBMAB-T1133-YJ)

Name: Mouse Anti-TBC1D20 Recombinant Antibody (CBYJT-2039)
SKU: CBMAB-T1133-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2039

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 289-420 mapping at the C-terminus of Taspase 1 of human origin

Specificity

Human, Rat, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 289-420

More Infomation

Target

Full Name

TBC1 Domain Family Member 20

Introduction

TBC1D20 is a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. TBC1D20 and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of TBC1D20 inhibits replication of the virus and HCV infection. Mutations in TBC1D20 are associated with Warburg micro syndrome 4.

Entrez Gene ID

Human	128637
Mouse	67231
Rat	362237

UniProt ID

Human	Q96BZ9
Mouse	Q9D9I4
Rat	Q6AXR1

Alternative Names

TBC1 Domain Family Member 20; C20orf140; Chromosome 20 Open Reading Frame 140; TBC1 Domain Family, Member 20; WARBM4

Function

GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.

Biological Process

Biological Process acrosome assemblyIEA:Ensembl
Biological Process COPII-coated vesicle cargo loadingIMP:UniProtKB1 Publication
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportIMP:UniProtKB1 Publication
Biological Process Golgi organizationIMP:UniProtKB1 Publication
Biological Process lens fiber cell morphogenesisIEA:Ensembl
Biological Process lipid droplet organizationIEA:Ensembl
Biological Process positive regulation by host of viral genome replicationIMP:AgBase1 Publication
Biological Process positive regulation by virus of viral protein levels in host cellIMP:AgBase1 Publication
Biological Process positive regulation of ER to Golgi vesicle-mediated transportIMP:UniProtKB1 Publication
Biological Process positive regulation of GTPase activityIMP:UniProtKB1 Publication
Biological Process seminiferous tubule developmentIEA:Ensembl
Biological Process virion assemblyIMP:UniProtKB1 Publication

Cellular Location

Membrane

Involvement in disease

Warburg micro syndrome 4 (WARBM4):
A form of Warburg micro syndrome, a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe intellectual disability, spastic diplegia, and hypogonadism.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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