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Mouse Anti-TBC1D23 Monoclonal Antibody (2E4) (CBMAB-0222-LY)

This product is mouse monoclonal antibody recognizes TBC1D23 of human. The antibody 2E4 immunoassay techniques such as: IP, ELISA.
See all TBC1D23 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E4
Antibody Isotype
IgG1
Application
IP, ELISA

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TBC1D23
Introduction
This gene encodes the protein involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge.
Entrez Gene ID
55773
UniProt ID
Q9NUY8
Alternative Names
FLJ11046
Function
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707).
Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865).
Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865).
Plays a role in brain development, including in cortical neuron positioning (By similarity).
May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity).
May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).
Biological Process
Biological Process brain developmentIMP:UniProtKB2 Publications
Biological Process embryonic brain developmentISS:UniProtKB
Biological Process neuron projection developmentISS:UniProtKB
Biological Process retrograde transport, endosome to GolgiIMP:UniProtKB1 Publication
Biological Process vesicle tethering to GolgiIDA:UniProtKB1 Publication
Biological Process vesicle-mediated transportISS:UniProtKB
Cellular Location
Golgi apparatus, trans-Golgi network
Cytoplasmic vesicle
Localization to the trans-Golgi is regulated by ARL1 and ARL5B/ARL8. ARL1 increases Golgi localization, while ARL5B decreases it. Recruitment to the trans-Golgi network requires the presence of GOLGA1 and GOLGA4, but not that of FAM91A1 (PubMed:29084197, PubMed:28823706).
Recruited on AP-1-derived vesicles by WDR11 complex (PubMed:29426865).
Involvement in disease
Pontocerebellar hypoplasia 11 (PCH11):
A non-degenerative form of pontocerebellar hypoplasia, a disorder characterized by structural defects of the pons and cerebellum, evident upon brain imaging. PCH11 features include severely delayed psychomotor development with intellectual disability and poor speech, microcephaly, dysmorphic features, and pontocerebellar hypoplasia. PCH11 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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