Mouse Anti-TBL2 Recombinant Antibody (CBYJT-2108) (CBMAB-T1207-YJ)

Name: Mouse Anti-TBL2 Recombinant Antibody (CBYJT-2108)
SKU: CBMAB-T1207-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2108

Application

ELISA, WB, IHC

Specificity

Human

Antibody Isotype

IgA

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Transducin Beta Like 2

Introduction

TBL2 is a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. TBL2 is possibly involved in some intracellular signaling pathway. TBL2 is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.

Entrez Gene ID

26608

UniProt ID

Q9Y4P3

Alternative Names

Transducin Beta Like 2; Williams-Beuren Syndrome Chromosome Region 13; WS Beta-Transducin Repeats Protein; WS-BetaTRP; WBSCR13; Williams-Beuren Syndrome Chromosomal Region 13 Protein; Transducin Beta-Like Protein 2; Transducin (Beta)-Like 2; Transducin -Like 2

Biological Process

Biological Process cellular response to glucose starvationIMP:ParkinsonsUK-UCL1 Publication
Biological Process cellular response to hypoxiaIMP:ParkinsonsUK-UCL1 Publication
Biological Process endoplasmic reticulum unfolded protein responseIMP:ParkinsonsUK-UCL1 Publication

Cellular Location

endoplasmic reticulum
integral component of endoplasmic reticulum membrane

Involvement in disease

TBL2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of TBL2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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