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Mouse Anti-TBL2 Recombinant Antibody (CBYJT-2108) (CBMAB-T1207-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2108
Antibody Isotype
IgA
Application
ELISA, WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgA
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transducin Beta Like 2
Introduction
TBL2 is a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. TBL2 is possibly involved in some intracellular signaling pathway. TBL2 is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.
Entrez Gene ID
26608
UniProt ID
Q9Y4P3
Alternative Names
Transducin Beta Like 2; Williams-Beuren Syndrome Chromosome Region 13; WS Beta-Transducin Repeats Protein; WS-BetaTRP; WBSCR13; Williams-Beuren Syndrome Chromosomal Region 13 Protein; Transducin Beta-Like Protein 2; Transducin (Beta)-Like 2; Transducin -Like 2
Biological Process
Biological Process cellular response to glucose starvationIMP:ParkinsonsUK-UCL1 Publication
Biological Process cellular response to hypoxiaIMP:ParkinsonsUK-UCL1 Publication
Biological Process endoplasmic reticulum unfolded protein responseIMP:ParkinsonsUK-UCL1 Publication
Cellular Location
endoplasmic reticulum
integral component of endoplasmic reticulum membrane
Involvement in disease
TBL2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of TBL2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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