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Mouse Anti-TBX22 Recombinant Antibody (CBYJT-2153) (CBMAB-T1258-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBX22 (T-Box 22). The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all TBX22 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2153
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa431-520 from human TBX22 (NP_058650) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 431-520

Target

Full Name
T-box 22
Introduction
TBX22 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in TBX22 have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis.
Entrez Gene ID
50945
UniProt ID
Q9Y458
Alternative Names
T-Box 22; T-Box Protein 22; Cleft Palate And/Or Ankyloglossia; T-Box Transcription Factor TBX22; DJ795G23.1; TBOX22
Function
Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.
Biological Process
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process negative regulation of DNA-templated transcriptionIDA:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcriptionIEA:InterPro
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Cleft palate with or without ankyloglossia, X-linked (CPX):
A congenital mouth abnormality characterized by fissure of the soft and/or hard palate, due to faulty fusion. Some patients also manifest ankyloglossia, a condition in which movements of the tongue are restricted. Complete ankyloglossia is due to fusion between the tongue and the floor of the mouth. Partial ankyloglossia is due to a short lingual frenum or one which is attached too near the tip of the tongue.
Abruzzo-Erickson syndrome (ABERS):
A disease characterized by cleft palate, coloboma, hypospadias, deafness, short stature, and radial synostosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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