Sign in or Register   Sign in or Register
  |  

Mouse Anti-TBXT Monoclonal Antibody (1A5) (CBMAB-0211-LY)

This product is mouse monoclonal antibody recognizes TBXT of human. The antibody 1A5 immunoassay techniques such as: IP, WB, MA.
See all TBXT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A5
Antibody Isotype
IgG2c
Application
IP, MA, WB

Basic Information

Immunogen
Recombinant peptide (aa 37-196)
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TBXT Gene(Protein Coding) T-Box Transcription Factor T
Introduction
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
Entrez Gene ID
6862
UniProt ID
O15178
Function
Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site.
Biological Process
Biological Process anterior/posterior axis specification, embryoTAS:ProtInc1 Publication
Biological Process cardiac muscle cell myoblast differentiationIDA:BHF-UCL1 Publication
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process heart morphogenesisIDA:BHF-UCL1 Publication
Biological Process mesoderm developmentTAS:ProtInc1 Publication
Biological Process mesoderm formationIBA:GO_Central1 Publication
Biological Process negative regulation of DNA-binding transcription factor activityISS:BHF-UCL
Biological Process negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process primitive streak formationNAS:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process signal transductionNAS:ProtInc1 Publication
Biological Process somitogenesisIBA:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Neural tube defects (NTD):
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
Chordoma (CHDM):
Rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues and rarely, distant metastatic spread.
Sacral agenesis with vertebral anomalies (SAVA):
A disorder characterized by abnormalities of the spine, including sacral agenesis, abnormal ossification of all vertebral bodies, and a persistent notochordal canal during development.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TBXT Monoclonal Antibody (1A5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare