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Mouse Anti-TCEA1 Recombinant Antibody (CBYJT-2216) (CBMAB-T1322-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2216
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa81-185 from human TCEA1 (NP_006747) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 81-185

Target

Full Name
transcription elongation factor A (SII), 1
Introduction
TCEA1 (Transcription Elongation Factor A1) is necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Entrez Gene ID
6917
UniProt ID
P23193
Alternative Names
Transcription Elongation Factor A1; Transcription Elongation Factor S-II Protein 1; Transcription Elongation Factor A (SII), 1; Transcription Elongation Factor TFIIS.O; Transcription Factor IIS; GTF2S
Biological Process
Biological Process DNA-templated transcriptionIBA:GO_Central1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process transcription by RNA polymerase IITAS:ProtInc1 Publication
Biological Process transcription elongation by RNA polymerase II promoterIEA:InterPro
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.
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For research use only. Not intended for any clinical use.

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