Mouse Anti-TCTN2 Recombinant Antibody (CBYJT-2425) (CBMAB-T1570-YJ)

Name: Mouse Anti-TCTN2 Recombinant Antibody (CBYJT-2425)
SKU: CBMAB-T1570-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2425

Application

FC, ICC, IF, WB

Immunogen

Full length human recombinant protein of human TCTN2 (NP_079085) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Tectonic Family Member 2

Introduction

TCTN2 is a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in TCTN2 are associated with Meckel syndrome type 8.

Entrez Gene ID

79867

UniProt ID

Q96GX1

Alternative Names

Tectonic Family Member 2; C12orf38; TECT2; Chromosome 12 Open Reading Frame 38; Meckel Syndrome, Type 8; Tectonic-2; JBTS24; MKS8

Function

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity).

Biological Process

Biological Process cilium assemblyISS:UniProtKB
Biological Process protein localization to ciliary transition zoneIBA:GO_Central1 Publication
Biological Process smoothened signaling pathwayISS:UniProtKB

Cellular Location

Membrane
Cytoplasm, cytoskeleton, cilium basal body
Localizes at the transition zone, a region between the basal body and the ciliary axoneme.

Involvement in disease

Meckel syndrome 8 (MKS8):
A disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly.
Joubert syndrome 24 (JBTS24):
A form of Joubert syndrome, a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy, renal disease, liver fibrosis, and polydactyly.

Topology

Extracellular: 26-668
Helical: 669-689
Cytoplasmic: 690-697

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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