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Mouse Anti-TEAD3 Recombinant Antibody (CBYJT-2481) (CBMAB-T1630-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TEAD3 (TEA Domain Transcription Factor 3). The antibody can be used for immunoassay techniques, such as ELISA, IF.
See all TEAD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2481
Antibody Isotype
IgG2b, κ
Application
ELISA, IF

Basic Information

Immunogen
Partial recombinant corresponding to aa215-303 from human TEAD3 (NP_003205) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 215-303

Target

Full Name
TEAD3
Introduction
TEAD3 is a transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. TEAD3 acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. It binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Entrez Gene ID
7005
UniProt ID
Q99594
Alternative Names
TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Biological Process
Biological Process asymmetric neuroblast divisionIGI:UniProtKB1 Publication
Biological Process embryonic organ developmentIBA:GO_Central1 Publication
Biological Process female pregnancyTAS:ProtInc1 Publication
Biological Process hippo signalingIDA:UniProtKB2 Publications
Biological Process positive regulation of transcription by RNA polymerase IIIEA:InterPro
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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