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Mouse Anti-TEC Recombinant Antibody (CBYJT-2490) (CBMAB-T1639-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TEC (Tec Protein Tyrosine Kinase). The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC-P, IF, ICC, FC.
See all TEC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2490
Antibody Isotype
IgG1
Application
ELISA, WB, IHC-P, IF, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of TEC expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Ascites
Preservative
0.03% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TEC Gene(Protein Coding) Tec Protein Tyrosine Kinase
Introduction
TEC belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. TEC may be associated with myelodysplastic syndrome.
Entrez Gene ID
7006
UniProt ID
P42680
Alternative Names
Tec Protein Tyrosine Kinase; EC 2.7.10.2; PSCTK4; Tyrosine-Protein Kinase Tec; EC 2.7.10
Function
Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.
Biological Process
Biological Process adaptive immune responseIBA:GO_Central1 Publication
Biological Process B cell receptor signaling pathwayIDA:UniProtKB1 Publication
Biological Process integrin-mediated signaling pathwayIDA:UniProtKB1 Publication
Biological Process intracellular signal transductionTAS:ProtInc1 Publication
Biological Process protein phosphorylationTAS:ProtInc1 Publication
Biological Process regulation of platelet activationIDA:UniProtKB2 Publications
Biological Process T cell receptor signaling pathwayIBA:GO_Central1 Publication
Biological Process tissue regenerationIBA:GO_Central1 Publication
Cellular Location
Cytoplasm
Cell membrane
Cytoplasm, cytoskeleton
Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity).
PTM
Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-519. Undergoes also tyrosine phosphorylation during platelet activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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