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Mouse Anti-TELO2 Recombinant Antibody (CBYJT-2515) (CBMAB-T1668-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2515
Antibody Isotype
IgG1
Application
ELISA, WB, IP, IHC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TELO2 Telomere Maintenance 2
Introduction
TELO2 is a protein that plays a role as an S-phase checkpoint protein in the cell cycle. TELO2 may also function in DNA repair.
Entrez Gene ID
9894
UniProt ID
Q9Y4R8
Alternative Names
Telomere Maintenance 2; Protein Clk-2 Homolog; TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae); Telomere Length Regulation Protein TEL2 Homolog; TEL2, Telomere Maintenance 2, Homolog; EC 1.1.1.27; EC 2.7.11.1
Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.
Biological Process
Biological Process positive regulation of DNA damage checkpointSource:ComplexPortal1 Publication
Biological Process positive regulation of protein serine/threonine kinase activitySource:UniProtKB1 Publication
Biological Process positive regulation of TORC1 signalingSource:UniProtKB1 Publication
Biological Process positive regulation of TORC2 signalingSource:UniProtKB1 Publication
Biological Process protein stabilizationSource:UniProtKB1 Publication
Biological Process regulation of TOR signalingSource:UniProtKB1 Publication
Biological Process telomere maintenance via telomeraseSource:GO_Central1 Publication
Involvement in disease
You-Hoover-Fong syndrome (YHFS):
A syndrome characterized by severe global developmental delay, intellectual disability, dysmorphic facial features, microcephaly, abnormal movements, congenital heart disease comprising developmental abnormalities of the great vessels, and abnormal auditory and visual function. The transmission pattern is consistent with autosomal recessive inheritance.
PTM
Hydroxylation by PHD3 is required for a proper interaction with ATR, and activation of the ATR/CHK1/p53 pathway following DNA damage.
Phosphorylated at Ser-485 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1-associated protein.
Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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