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Mouse Anti-TFEC Recombinant Antibody (CBYJT-2672) (CBMAB-T1854-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TFEC (Transcription Factor EC). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TFEC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2672
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transcription factor EC
Introduction
TFEC is a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. TFEC is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor.
Entrez Gene ID
22797
UniProt ID
O14948
Alternative Names
Transcription Factor EC; Class E Basic Helix-Loop-Helix Protein 34; BHLHe34; HTFEC-L; TCFEC; TFE-C; TFECL; Transcription Factor EC-Like; TFEC-L
Function
Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity).
Collaborates with MITF in target gene activation (By similarity).
Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity).
Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity).
Binds DNA in a homo- or heterodimeric form.
Biological Process
Biological Process cellular response to heatSource:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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