Mouse Anti-TFEC Recombinant Antibody (CBYJT-2672) (CBMAB-T1854-YJ)

Name: Mouse Anti-TFEC Recombinant Antibody (CBYJT-2672)
SKU: CBMAB-T1854-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2672

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

transcription factor EC

Introduction

TFEC is a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. TFEC is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor.

Entrez Gene ID

22797

UniProt ID

O14948

Alternative Names

Transcription Factor EC; Class E Basic Helix-Loop-Helix Protein 34; BHLHe34; HTFEC-L; TCFEC; TFE-C; TFECL; Transcription Factor EC-Like; TFEC-L

Function

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity).
Collaborates with MITF in target gene activation (By similarity).
Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity).
Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity).
Binds DNA in a homo- or heterodimeric form.

Biological Process

Biological Process cellular response to heatSource:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-TFEC Recombinant Antibody (CBYJT-2671) (CAT#: CBMAB-T1853-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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