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Mouse Anti-TFG Recombinant Antibody (CBYJT-2695) (CBMAB-T1882-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TFG (TRK-Fused Gene). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TFG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2695
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TRK-Fused Gene
Introduction
There are several documented fusion oncoproteins encoded partially by TFG. TFG also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may function in the NF-kappaB pathway.
Entrez Gene ID
10342
UniProt ID
Q92734
Alternative Names
TRK-Fused Gene; TRK-Fused Gene Protein; TRKT3 Oncogene; Protein TFG; HMSNP; SPG57; TRKT3; TF6
Function
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252).
Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858).
Biological Process
Biological Process COPII vesicle coatingSource:InterPro
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportSource:UniProtKB2 Publications
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Cellular Location
Endoplasmic reticulum
Localizes to endoplasmic reticulum exit site (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:27813252, PubMed:21478858).
Involvement in disease
Neuropathy, hereditary motor and sensory, Okinawa type (HMSNO):
A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis.
Spastic paraplegia 57, autosomal recessive (SPG57):
A complicated form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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