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Mouse Anti-THBD Recombinant Antibody (THBD/1591) (CBMAB-T2160-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to THBD (Thrombomodulin). The antibody can be used for immunoassay techniques, such as WB, FC, ELISA, ICC, IF, IHC-P, CyTOF.
See all THBD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
THBD/1591
Antibody Isotype
IgG2b, κ
Application
WB, FC, ELISA, ICC, IF, IHC-P, CyTOF

Basic Information

Immunogen
Recombinant human Thrombomodulin protein fragment (aa69-194) (exact sequence is proprietary)
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 69-194

Target

Full Name
THBD Gene(Protein Coding) Thrombomodulin
Introduction
THBD is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in THBD are a cause of thromboembolic disease, also known as inherited thrombophilia.
Entrez Gene ID
7056
UniProt ID
P07204
Alternative Names
Thrombomodulin; CD141 Antigen; Fetomodulin; THRM; TM; THPH12; AHUS6; BDCA3; CD141
Function
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Biological Process
Biological Process blood coagulationSource:ProtInc1 Publication
Biological Process blood coagulation, common pathwaySource:ComplexPortal1 Publication
Biological Process female pregnancySource:Ensembl
Biological Process negative regulation of blood coagulationSource:BHF-UCL1 Publication
Biological Process negative regulation of fibrinolysisSource:BHF-UCL1 Publication
Biological Process negative regulation of platelet activationSource:BHF-UCL1 Publication
Biological Process proteolysisSource:ComplexPortal1 Publication
Biological Process response to cAMPSource:Ensembl
Biological Process response to lipopolysaccharideSource:Ensembl
Biological Process response to X-raySource:Ensembl
Biological Process zymogen activationSource:ComplexPortal1 Publication
Cellular Location
Membrane
Involvement in disease
Thrombophilia due to thrombomodulin defect (THPH12):
A hemostatic disorder characterized by a tendency to thrombosis.
Hemolytic uremic syndrome atypical 6 (AHUS6):
An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
Topology
Extracellular: 19-515
Helical: 516-539
Cytoplasmic: 540-575
PTM
N-glycosylated.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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