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Mouse Anti-THG1L Recombinant Antibody (CBYJT-2982) (CBMAB-T2229-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to THG1L (TRNA-Histidine Guanylyltransferase 1 Like). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all THG1L antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2982
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
THG1L (AAH01523, 1 a.a. ~ 269 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-269

Target

Full Name
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
Introduction
THG1L is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. THG1L appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of it is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His).
Entrez Gene ID
UniProt ID
Alternative Names
TRNA-Histidine Guanylyltransferase 1 Like; Interphase Cytoplasmic Foci Protein 45; Induced By High Glucose-1; ICF45; TRNA-Histidine Guanylyltransferase 1-Like (S. Cerevisiae); TRNA-Histidine Guanylyltransferase 1-Like; Probable TRNA(His) Guanylyltransferase
Function
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion (PubMed:25008184, PubMed:27307223).
By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress (PubMed:25008184, PubMed:27307223).
Biological Process
Biological Process mitochondrial fusionSource:UniProtKB1 Publication
Biological Process protein homotetramerizationSource:UniProtKB1 Publication
Biological Process response to oxidative stressSource:UniProtKB1 Publication
Biological Process stress-induced mitochondrial fusionSource:UniProtKB1 Publication
Biological Process tRNA modificationSource:UniProtKB
Biological Process tRNA processingSource:UniProtKB1 Publication
Cellular Location
Cytoplasm
Mitochondrion outer membrane
Involvement in disease
Spinocerebellar ataxia, autosomal recessive, 28 (SCAR28):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR28 patients manifest mild motor developmental delay, gait ataxia, and dysarthria. Some patients show mildly impaired intellectual development. Disease onset is in early childhood.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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