Mouse Anti-THG1L Recombinant Antibody (CBYJT-2982) (CBMAB-T2229-YJ)

Name: Mouse Anti-THG1L Recombinant Antibody (CBYJT-2982)
SKU: CBMAB-T2229-YJ
Rating: 5 (1 reviews)

See all THG1L antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-2982

Application

ELISA, WB

Immunogen

THG1L (AAH01523, 1 a.a. ~ 269 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-269

More Infomation

Target

Full Name

tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)

Introduction

THG1L is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. THG1L appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of it is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His).

Entrez Gene ID

54974

UniProt ID

Q9NWX6

Alternative Names

TRNA-Histidine Guanylyltransferase 1 Like; Interphase Cytoplasmic Foci Protein 45; Induced By High Glucose-1; ICF45; TRNA-Histidine Guanylyltransferase 1-Like (S. Cerevisiae); TRNA-Histidine Guanylyltransferase 1-Like; Probable TRNA(His) Guanylyltransferase

Function

Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion (PubMed:25008184, PubMed:27307223).
By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress (PubMed:25008184, PubMed:27307223).

Biological Process

Biological Process mitochondrial fusionSource:UniProtKB1 Publication
Biological Process protein homotetramerizationSource:UniProtKB1 Publication
Biological Process response to oxidative stressSource:UniProtKB1 Publication
Biological Process stress-induced mitochondrial fusionSource:UniProtKB1 Publication
Biological Process tRNA modificationSource:UniProtKB
Biological Process tRNA processingSource:UniProtKB1 Publication

Cellular Location

Cytoplasm
Mitochondrion outer membrane

Involvement in disease

Spinocerebellar ataxia, autosomal recessive, 28 (SCAR28):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR28 patients manifest mild motor developmental delay, gait ataxia, and dysarthria. Some patients show mildly impaired intellectual development. Disease onset is in early childhood.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-THG1L Recombinant Antibody (CBYJT-2982)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry