Rat Anti-Ticam2 Recombinant Antibody (CBYJT-3127) (CBMAB-T2395-YJ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819).
Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567).
Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606).
Isoform 2
Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportSource:GO_Central1 Publication
Biological Process Golgi organizationSource:GO_Central1 Publication
Biological Process inflammatory responseSource:UniProtKB-KW
Biological Process innate immune responseSource:UniProtKB-KW
Biological Process intracellular protein transportSource:GO_Central1 Publication
Biological Process negative regulation of chemokine (C-C motif) ligand 5 productionSource:UniProtKB
Biological Process negative regulation of toll-like receptor 4 signaling pathwaySource:UniProtKB
Biological Process phagocytosisSource:UniProtKB1 Publication
Biological Process positive regulation of chemokine (C-C motif) ligand 5 productionSource:UniProtKB
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process positive regulation of interleukin-18-mediated signaling pathwaySource:UniProtKB1 Publication
Biological Process positive regulation of toll-like receptor 4 signaling pathwaySource:UniProtKB1 Publication
Biological Process TRAM-dependent toll-like receptor 4 signaling pathwaySource:UniProtKB1 Publication
Cytoplasm
Golgi apparatus
Cell membrane
Endoplasmic reticulum
Early endosome membrane
Late endosome membrane
Cell projection, phagocytic cup
Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.
Isoform 2
Endoplasmic reticulum
Early endosome membrane
Late endosome membrane
Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1.
Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Antibody Pairs
TICAM2 Matched Antibody Pair (1206) (CAT#: APMAB-1206LY)
Related Products
Rat Anti-Ticam2 Recombinant Antibody (CBYJT-3126) (CAT#: CBMAB-T2394-YJ)
Mouse Anti-TICAM2 Recombinant Antibody (CBYJT-3125) (CAT#: CBMAB-T2393-YJ)
Mouse Anti-TICAM2 Recombinant Antibody (CBYJT-3124) (CAT#: CBMAB-T2392-YJ)
TICAM2 Matched Antibody Pair (1206) (CAT#: APMAB-1206LY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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