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Rabbit Anti-TIMM50 Recombinant Antibody (CBYJT-3176) (CBMAB-T2450-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TIMM50 (Translocase Of Inner Mitochondrial Membrane 50). The antibody can be used for immunoassay techniques, such as WB, IHC-P.
See all TIMM50 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBYJT-3176
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
A synthetic peptide corresponding to residues in human TIMM50 was used as an immunogen
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.05% BSA, 50% Glycerol
Preservative
0.01% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Translocase Of Inner Mitochondrial Membrane 50
Introduction
TIMM50 is a subunit of the TIM23 inner mitochondrial membrane translocase complex. TIMM50 plays a role as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. TIMM50 may also function in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis.
Entrez Gene ID
Human92609
Mouse66525
UniProt ID
HumanQ3ZCQ8
MouseQ9D880
Alternative Names
Translocase Of Inner Mitochondrial Membrane 50; TIM50; Translocase Of Inner Mitochondrial Membrane 50 Homolog (Yeast); Mitochondrial Import Inner Membrane Translocase Subunit TIM50; Homolog Of Yeast Tim50; Tim50-Like Protein; TIM50L; MGCA9
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.
Isoform 2
May participate in the release of snRNPs and SMN from the Cajal body.
Biological Process
Biological Process intracellular protein transportSource:ComplexPortal1 Publication
Biological Process mitochondrial membrane organizationSource:UniProtKB1 Publication
Biological Process protein dephosphorylationSource:UniProtKB1 Publication
Biological Process protein import into mitochondrial matrixSource:GO_Central1 Publication
Biological Process release of cytochrome c from mitochondriaSource:MGI1 Publication
Cellular Location
Mitochondrion inner membrane
Isoform 2
Nucleus speckle
Nuclear and enriched in speckles with snRNPs.
Involvement in disease
3-methylglutaconic aciduria 9 (MGCA9):
An autosomal recessive disease characterized by early-onset seizures, severely delayed psychomotor development and intellectual disability. Patients have hypotonia or spasticity, and laboratory investigations show increased serum lactate and 3-methylglutaconic aciduria.
Topology
Mitochondrial matrix: 45-65
Helical: 66-86
Mitochondrial intermembrane: 87-353
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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