Rabbit Anti-TIMM50 Recombinant Antibody (CBYJT-3176) (CBMAB-T2450-YJ)

Name: Rabbit Anti-TIMM50 Recombinant Antibody (CBYJT-3176)
SKU: CBMAB-T2450-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBYJT-3176

Application

WB, IHC-P

Immunogen

A synthetic peptide corresponding to residues in human TIMM50 was used as an immunogen

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, 0.05% BSA, 50% Glycerol

Preservative

0.01% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Translocase Of Inner Mitochondrial Membrane 50

Introduction

TIMM50 is a subunit of the TIM23 inner mitochondrial membrane translocase complex. TIMM50 plays a role as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. TIMM50 may also function in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis.

Entrez Gene ID

Human	92609
Mouse	66525

UniProt ID

Human	Q3ZCQ8
Mouse	Q9D880

Alternative Names

Translocase Of Inner Mitochondrial Membrane 50; TIM50; Translocase Of Inner Mitochondrial Membrane 50 Homolog (Yeast); Mitochondrial Import Inner Membrane Translocase Subunit TIM50; Homolog Of Yeast Tim50; Tim50-Like Protein; TIM50L; MGCA9

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.
Isoform 2
May participate in the release of snRNPs and SMN from the Cajal body.

Biological Process

Biological Process intracellular protein transportSource:ComplexPortal1 Publication
Biological Process mitochondrial membrane organizationSource:UniProtKB1 Publication
Biological Process protein dephosphorylationSource:UniProtKB1 Publication
Biological Process protein import into mitochondrial matrixSource:GO_Central1 Publication
Biological Process release of cytochrome c from mitochondriaSource:MGI1 Publication

Cellular Location

Mitochondrion inner membrane
Isoform 2
Nucleus speckle
Nuclear and enriched in speckles with snRNPs.

Involvement in disease

3-methylglutaconic aciduria 9 (MGCA9):
An autosomal recessive disease characterized by early-onset seizures, severely delayed psychomotor development and intellectual disability. Patients have hypotonia or spasticity, and laboratory investigations show increased serum lactate and 3-methylglutaconic aciduria.

Topology

Mitochondrial matrix: 45-65
Helical: 66-86
Mitochondrial intermembrane: 87-353

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TIMM50 Recombinant Antibody (CBYJT-3178) (CAT#: CBMAB-T2452-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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