Mouse Anti-TIMM8A Recombinant Antibody (CBYJT-3181) (CBMAB-T2455-YJ)

Name: Mouse Anti-TIMM8A Recombinant Antibody (CBYJT-3181)
SKU: CBMAB-T2455-YJ
Rating: 5 (1 reviews)

See all TIMM8A antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-3181

Application

ELISA, IHC, WB

Immunogen

Partial recombinant corresponding to aa9-97 from human TIMM8A (NP_004076) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 9-97

More Infomation

Target

Full Name

translocase of inner mitochondrial membrane 8 homolog A (yeast)

Introduction

TIMM8A is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. TIMM8A is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in TIMM8A also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer.

Entrez Gene ID

1678

UniProt ID

O60220

Alternative Names

Translocase Of Inner Mitochondrial Membrane 8A; X-Linked Deafness Dystonia Protein; Deafness Dystonia Protein 1; DDP1; DDP; Translocase Of Inner Mitochondrial Membrane 8 (Yeast) Homolog A; Translocase Of Inner Mitochondrial Membrane 8 Homolog A (Yeast); Mitochondrial Import Inner Membrane Translocase Subunit Tim8 A

Function

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.

Biological Process

Biological Process nervous system developmentSource:ProtInc1 Publication
Biological Process protein insertion into mitochondrial inner membraneSource:BHF-UCL1 Publication

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Mohr-Tranebjaerg syndrome (MTS):
An X-linked recessive disorder characterized by postlingual sensorineural deafness with onset in early childhood, dystonia, spasticity, dysphagia, mental deterioration, paranoia and cortical blindness.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-TIMM8A Recombinant Antibody (CBYJT-3181)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TIMM8A Recombinant Antibody (9G347) (CAT#: CBMAB-D2276-YC)

Mouse Anti-TIMM8A Recombinant Antibody (CBYJT-3180) (CAT#: CBMAB-T2454-YJ)

Mouse Anti-TIMM8A (C-terminus) Recombinant Antibody (CBFYM-3157) (CAT#: CBMAB-M3354-FY)

Mouse Anti-TIMM8A Recombinant Antibody (2F11) (CAT#: CBMAB-A9102-LY)

Mouse Anti-TIMM8A Recombinant Antibody (CBYJT-3179) (CAT#: CBMAB-T2453-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry