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Mouse Anti-TIMM8B Recombinant Antibody (CBYJT-3182) (CBMAB-T2456-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TIMM8B (Translocase Of Inner Mitochondrial Membrane 8 Homolog B). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TIMM8B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3182
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
TIMM8B (NP_036591, 1 a.a. ~ 83 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MAELGEADEA ELQRLVAAEQ QKAQFTAQVH HFMELCWDKC VEKPGNRLDS RTENCLSSCV DRFIDTTLAI TSRFAQIVQK GGQ
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-83

Target

Full Name
translocase of inner mitochondrial membrane 8 homolog B (yeast)
Introduction
TIMM8B is a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. TIMM8B is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.
Entrez Gene ID
26521
UniProt ID
Q9Y5J9
Alternative Names
Translocase Of Inner Mitochondrial Membrane 8 Homolog B; Mitochondrial Import Inner Membrane Translocase Subunit Tim8 B; Deafness Dystonia Protein 2; DDP-Like Protein; TIM8B; DDP2; Translocase Of Inner Mitochondrial Membrane 8 Homolog B (Yeast); DDPL
Function
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
Biological Process
Biological Process protein insertion into mitochondrial inner membraneSource:FlyBase
Biological Process protein targeting to mitochondrionSource:ProtInc1 Publication
Biological Process sensory perception of soundSource:ProtInc1 Publication
Cellular Location
Mitochondrion inner membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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