Sign in or Register   Sign in or Register
  |  

Rat Anti-Tjp1 Recombinant Antibody (CBMAB-0671-LY)

This product is rat antibody recognizes Tjp1 of mouse. The antibody immunoassay techniques such as: IF, IHC, IP, WB.
See all Tjp1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse, Dog, Fish, Pig, Rat, Zebrafish
Antibody Isotype
IgG1
Application
IF, IHC, IP, WB

Basic Information

Specificity
Mouse, Dog, Fish, Pig, Rat, Zebrafish
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
tight junction protein 1
Entrez Gene ID
Mouse21872
Dog403752
Rat292994
Pig100736682
Zebrafish378845
UniProt ID
MouseP39447
DogO97758
RatA0A0G2K2P5
PigF1SNQ1
ZebrafishE7F2W2
Alternative Names
Zo1
Function
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688).
The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity).
Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187).
Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113).
With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).
Biological Process
Biological Process actomyosin structure organizationSource:ARUK-UCL1 Publication
Biological Process adherens junction maintenanceSource:ARUK-UCL1 Publication
Biological Process cell-cell adhesionSource:GO_Central1 Publication
Biological Process cell-cell junction assemblySource:ProtInc1 Publication
Biological Process cell-cell junction organizationSource:ARUK-UCL1 Publication
Biological Process establishment of endothelial intestinal barrierSource:UniProtKB1 Publication
Biological Process maintenance of blood-brain barrierSource:ARUK-UCL1 Publication
Biological Process negative regulation of actin cytoskeleton reorganizationSource:ARUK-UCL1 Publication
Biological Process negative regulation of apoptotic processSource:ARUK-UCL1 Publication
Biological Process negative regulation of stress fiber assemblySource:ARUK-UCL
Biological Process positive regulation of blood-brain barrier permeabilitySource:ARUK-UCL1 Publication
Biological Process positive regulation of cell migrationSource:ARUK-UCL1 Publication
Biological Process positive regulation of cell population proliferationSource:ARUK-UCL1 Publication
Biological Process positive regulation of cell-cell adhesion mediated by cadherinSource:ARUK-UCL1 Publication
Biological Process positive regulation of sprouting angiogenesisSource:ARUK-UCL1 Publication
Biological Process protein localization to adherens junctionSource:ARUK-UCL1 Publication
Biological Process protein localization to bicellular tight junctionSource:ARUK-UCL1 Publication
Biological Process protein localization to cell-cell junctionSource:ARUK-UCL1 Publication
Biological Process regulation of bicellular tight junction assemblySource:ARUK-UCL1 Publication
Biological Process regulation of cell junction assemblySource:ARUK-UCL1 Publication
Biological Process regulation of cytoskeleton organizationSource:ARUK-UCL1 Publication
PTM
Phosphorylated at tyrosine redidues in response to epidermal growth factor (EGF) (PubMed:19332538, PubMed:7542259).
This response is dependent on an intact actin microfilament system (PubMed:7542259).
Dephosphorylated by PTPRJ (PubMed:19332538).
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-Tjp1 Recombinant Antibody?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare