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Mouse Anti-TMEM59 Recombinant Antibody (CBYJT-3523) (CBMAB-T2848-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3523
Antibody Isotype
IgG1
Application
ICC

Basic Information

Immunogen
E. coli-derived recombinant human TMEM59, Met1-Asn220, Accession # Q9BXS4
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-220

Target

Full Name
Transmembrane Protein 59
Introduction
TMEM59 is a protein shown to regulate autophagy in response to bacterial infection. TMEM59 may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of TMEM59 has been found to promote apoptosis in a glioma cell line.
Entrez Gene ID
9528
UniProt ID
Q9BXS4
Alternative Names
Transmembrane Protein 59; Liver Membrane-Bound Protein; C1orf8; Chromosome 1 Open Reading Frame 8; Dendritic Cell Factor 1; HSPC001; PRO195; UNQ169; DCF1
Function
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921).
Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278).
Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).
Biological Process
Biological Process autophagySource:UniProtKB-KW
Biological Process negative regulation of protein localization to plasma membraneSource:UniProtKB1 Publication
Biological Process positive regulation of autophagySource:UniProtKB1 Publication
Biological Process protein glycosylationSource:UniProtKB1 Publication
Cellular Location
Late endosome membrane
Lysosome membrane
Cell membrane
Golgi apparatus membrane
Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded.
Topology
Extracellular: 36-238
Helical: 239-259
Cytoplasmic: 260-323
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

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