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Mouse Anti-TMEM70 Recombinant Antibody (CBYJT-3525) (CBMAB-T2850-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TMEM70 (Transmembrane Protein 70). The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC.
See all TMEM70 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYJT-3525
Antibody Isotype
IgG2b
Application
ELISA, WB, IHC

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TMEM70 Transmembrane Protein 70
Introduction
TMEM70 likely encodes a mitochondrial membrane protein. TMEM70 may function in biogenesis of mitochondrial ATP synthase. Mutations in TMEM70 have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency.
Entrez Gene ID
Human54968
Mouse70397
UniProt ID
HumanQ9BUB7
MouseQ921N7
Alternative Names
Transmembrane Protein 70; Transmembrane Protein 70, Mitochondrial; MC5DN2
Function
Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F1F0 ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (PubMed:31652072, PubMed:33753518, PubMed:33359711, PubMed:32275929).
Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:33359711, PubMed:18953340, PubMed:20937241, PubMed:31652072).
In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (PubMed:32275929).
Biological Process
Biological Process mitochondrial proton-transporting ATP synthase complex assemblySource:UniProtKB5 Publications
Biological Process protein complex oligomerizationSource:UniProtKB1 Publication
Biological Process protein homooligomerizationSource:UniProtKB1 Publication
Cellular Location
Mitochondrion inner membrane
Mostly located within the inner cristae membrane.
Involvement in disease
Mitochondrial complex V deficiency, nuclear type 2 (MC5DN2):
A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid.
Topology
Mitochondrial matrix: 82-102
Helical: 103-123
Mitochondrial intermembrane: 124-141
Helical: 142-162
Mitochondrial matrix: 163-260
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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